As a visionary biomedical informatician, pediatrician, and biotech entrepreneur, Dr. Atul Butte leaves behind an extraordinary legacy, defined not only by his groundbreaking work in data-driven medicine, but also by his contagious positivity and unwavering commitment to uplifting others. He was as fierce an advocate for human potential as he was for scientific progress, and the fields of translational and clinical bioinformatics that he pioneered will benefit for generations to come. Here, we pay tribute to his transformative work and passion for human health. “Once we let data flow,lifelong discoveries become possible.” This statement truly defines the transformational achievements and life of Atul Butte, MD, PhD , a respected champion in the use of big data in science and health, and one of the most highly cited researchers in his field. When he walked on stage at a recent LSI USA event in Dana Point, CA to give a compelling keynote address, entitled “Precisely Practicing Medici...